Transcranial alternating current stimulation reduces symptoms in intractable idiopathic cervical dystonia: A case study

被引：24

作者：

Angelakis, E. ^{[1
]}

Liouta, E. ^{[1
]}

Andreadis, N. ^{[1
]}

Leonardos, A. ^{[1
]}

Ktonas, P. ^{[1
]}

Stavrinou, L. C. ^{[1
]}

Miranda, P. C. ^{[2
]}

Mekonnen, A. ^{[2
]}

Sakas, D. E. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Neurosurg, Hellen Ctr Neurosurg Res Prof Petros Kokkalis, Athens 11528, Greece

[2] Univ Lisbon, Fac Sci, Inst Biophys & Biomed Engn, P-1699 Lisbon, Portugal

来源：

NEUROSCIENCE LETTERS | 2013年 / 533卷

基金：

欧盟第七框架计划;

关键词：

Movement disorders; Motor cortex; Spasmodic torticollis; Brain stimulation; tDCS; tACS; CORTICAL EXCITABILITY; MOTOR; AREA; TACS;

D O I：

10.1016/j.neulet.2012.11.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Idiopathic cervical dystonia (ICD) is a movement disorder often resulting in profound disability and pain. Treatment options include oral medications or other invasive procedures, whereas intractable ICD has been shown to respond to invasive (deep) brain stimulation. In the present blinded, placebo-controlled case study, transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) has been applied to a 54-year old patient with intractable ICD. Results showed that 15 Hz tACS had both immediate and cumulative effects in dystonic symptom reduction, with a 54% reduction in the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score, and a 75% in the TWSTRS Pain Scale. These effects were persistent at 30-days follow-up. This is the first report to demonstrate a significant and lasting therapeutic effect of non-invasive electrical brain stimulation in dystonia. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：39 / 43

页数：5

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