Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface

被引：635

作者：

Busscher, Henk J. ^{[1
,2
]}

van der Mei, Henny C. ^{[1
,2
]}

Subbiahdoss, Guruprakash ^{[1
,2
]}

Jutte, Paul C. ^{[3
,4
]}

van den Dungen, Jan J. A. M. ^{[4
,5
]}

Zaat, Sebastian A. J. ^{[6
]}

Schultz, Marcus J. ^{[7
]}

Grainger, David W. ^{[8
,9
]}

机构：

[1] Univ Med Ctr Groningen, Dept BioMed Engn, NL-9713 AV Groningen, Netherlands

[2] Univ Groningen, NL-9713 AV Groningen, Netherlands

[3] Univ Med Ctr Groningen, Dept Orthopaed Surg, NL-9713 GZ Groningen, Netherlands

[4] Univ Groningen, NL-9713 GZ Groningen, Netherlands

[5] Univ Med Ctr Groningen, Dept Surg, NL-9713 GZ Groningen, Netherlands

[6] Univ Amsterdam, NL-1105 AZ Amsterdam, Netherlands

[7] Univ Amsterdam, Acad Med Ctr, Ctr Infect & Immun Amsterdam CINIMA, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands

[8] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA

[9] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 153期

关键词：

GLYCOL)-BASED POLYMER-COATINGS; CENTRAL VENOUS CATHETERS; BLOOD-STREAM INFECTIONS; PERI-IMPLANT TISSUE; BACTERIAL-COLONIZATION; IN-VITRO; STAPHYLOCOCCUS-EPIDERMIDIS; MICROBIAL ADHESION; HIP-ARTHROPLASTY; OPERATING-ROOM;

D O I：

10.1126/scitranslmed.3004528

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Biomaterial-associated infections occur on both permanent implants and temporary devices for restoration or support of human functions. Despite increasing use of biomaterials in an aging society, comparatively few biomaterials have been designed that effectively reduce the incidence of biomaterial-associated infections. This review provides design guidelines for infection-reducing strategies based on the concept that the fate of biomaterial implants or devices is a competition between host tissue cell integration and bacterial colonization at their surfaces.

引用

页数：10

共 98 条

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