Targeting TFIIH to inhibit host cell transcription by Rift Valley Fever Virus

被引：15

作者：

Dasgupta, A ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

来源：

MOLECULAR CELL | 2004年 / 13卷 / 04期

关键词：

D O I：

10.1016/S1097-2765(04)00092-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the February 20 issue of Cell, Le May et al. (2004) report that Rift Valley Fever Virus (RVFV) targets cellular transcriptional apparatus to inhibit RNA polymerase II-mediated transcription. Unlike polio and vesicular stomatitis viruses, both of which target the TATA binding protein (TBP), RVFV appears to target the basal transcription factor THIIH to induce shut-off of host cell transcription.

引用

页码：456 / 458

页数：3

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