Nuclear localization of β-catenin in adult mouse thalamus correlates with low levels of GSK-3β

被引：12

作者：

Lucas, JJ ^{[1
]}

Hernández, F ^{[1
]}

Avila, J ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, Ctr Biol Mol Severo Ochoa, CSIC, E-28049 Madrid, Spain

来源：

NEUROREPORT | 1999年 / 10卷 / 13期

关键词：

adult brain; beta-catenin; GSK-3; beta; nuclear localization; thalamus;

D O I：

10.1097/00001756-199909090-00002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BESIDES its well established role in development and tumorogenesis, nuclear translocation of beta-catenin has also been suggested to play a role in adult brain physiology and pathology. However, nuclear localization of beta-catenin has never been observed in adult brain tissue. Immunohistochemical analysis of beta-catenin distribution in the adult mouse brain revealed nuclear localization exclusively in the whole thalamus with the exception of the reticular nucleus. To investigate whether differences in the level of beta-catenin or GSK-3 beta (the enzyme that targets it for degradation by the proteasome) might account for the differential localization in thalamus we performed Western analysis of various brain tissues. The beta-catenin/GSK-3 beta ratio was higher in thalamus than in the rest of the brain, suggesting a key role of GSK-3 beta in this phenomenon. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：2699 / 2703

页数：5

共 21 条

[11] XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos [J].

Molenaar, M ;

vandeWetering, M ;

Oosterwegel, M ;

PetersonMaduro, J ;

Godsave, S ;

Korinek, V ;

Roose, J ;

Destree, O ;

Clevers, H .

CELL, 1996, 86 (03) :391-399

[12]

Moreno-Flores MT, 1999, J COMP NEUROL, V410, P556, DOI 10.1002/(SICI)1096-9861(19990809)410:4<556::AID-CNE4>3.0.CO

[13]

2-Q

[14] Direct association of presenilin-1 with β-catenin [J].

Murayama, M ;

Tanaka, S ;

Palacino, J ;

Murayama, O ;

Honda, T ;

Sun, XY ;

Yasutake, K ;

Nihonmatsu, N ;

Wolozin, B ;

Takashima, A .

FEBS LETTERS, 1998, 433 (1-2) :73-77

[15] Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex [J].

Nishimura, M ;

Yu, G ;

Levesque, G ;

Zhang, DM ;

Ruel, L ;

Chen, F ;

Milman, P ;

Holmes, E ;

Liang, Y ;

Kawarai, T ;

Jo, E ;

Supala, A ;

Rogaeva, E ;

Xu, DM ;

Janus, C ;

Levesque, L ;

Bi, Q ;

Duthie, M ;

Rozmahel, R ;

Mattila, K ;

Lannfelt, L ;

Westaway, D ;

Mount, HTJ ;

Woodgett, J ;

Fraser, PE ;

St George-Hyslop, P .

NATURE MEDICINE, 1999, 5 (02) :164-169

[16] Binding of GSK3 beta to the APC-beta-catenin complex and regulation of complex assembly [J].

Rubinfeld, B ;

Albert, I ;

Porfiri, E ;

Fiol, C ;

Munemitsu, S ;

Polakis, P .

SCIENCE, 1996, 272 (5264) :1023-1026

[17] Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription [J].

Sakanaka, C ;

Weiss, JB ;

Williams, LT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :3020-3023

[18] Localization of the adenomatous polyposis coli tumour suppressor protein in the mouse central nervous system [J].

Senda, T ;

Iino, S ;

Matsushita, K ;

Matsumine, A ;

Kobayashi, S ;

Akiyama, T .

NEUROSCIENCE, 1998, 83 (03) :857-866

[19] The catenin cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones [J].

Uchida, N ;

Honjo, Y ;

Johnson, KR ;

Wheelock, MJ ;

Takeichi, M .

JOURNAL OF CELL BIOLOGY, 1996, 135 (03) :767-779

[20] The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin [J].

Yu, G ;

Chen, FS ;

Levesque, G ;

Nishimura, M ;

Zhang, DM ;

Levesque, L ;

Rogaeva, E ;

Xu, DH ;

Liang, Y ;

Duthie, M ;

St George-Hyslop, PH ;

Fraser, PE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (26) :16470-16475

← 1 2 3 →