TOPping up ATR activity

被引：12

作者：

Bartek, J

Mailand, N

机构：

[1] Danish Canc Soc, Inst Canc Biol, DK-2100 Copenhagen, Denmark

[2] Danish Canc Soc, Ctr Genotox Stress Res, DK-2100 Copenhagen, Denmark

来源：

CELL | 2006年 / 124卷 / 05期

关键词：

D O I：

10.1016/j.cell.2006.02.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

引用

页码：888 / 890

页数：3

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