Claspin, a regulator of Chk1 in DNA replication stress pathway

被引：64

作者：

Chini, CCS ^{[1
]}

Chen, JJ ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Dept Oncol, Rochester, MN 55902 USA

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

关键词：

claspin; checkpoint kinase; DNA replication;

D O I：

10.1016/j.dnarep.2004.03.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Regulation of the vertebrate checkpoint kinase Chk1 involves several protein complexes including the recently identified protein Claspin. Claspin associates with Chk1 upon replication stress and DNA damage and is required for Chk1 activation in both Xenopus and human systems. More importantly, Claspin is involved in regulation of cell cycle checkpoints. Here, we discuss the emerging roles of Claspin in the Chk1 pathway and its functions in checkpoint control. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1033 / 1037

页数：5

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