Chk1 and Chk2 kinases in checkpoint control and cancer

被引：1269

作者：

Bartek, J ^{[1
]}

Lukas, J ^{[1
]}

机构：

[1] Danish Canc Soc, Inst Canc Biol, Dept Cell Cycle & Canc, DK-2100 Copenhagen, Denmark

来源：

CANCER CELL | 2003年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1535-6108(03)00110-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Accumulation of mutations and chromosomal aberrations is one of the hallmarks of cancer cells. This enhanced genetic instability is fueled by defects in the genome maintenance mechanisms including DNA repair and cell cycle checkpoint pathways. Here, we discuss the emerging roles of the mammalian Chk1 and Chk2 kinases as key signal transducers within the complex network of genome integrity checkpoints, as candidate tumor suppressors disrupted in sporadic as well as some hereditary malignancies and as potential targets of new anticancer therapies.

引用

页码：421 / 429

页数：9

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