Chk1 and Chk2 kinases in checkpoint control and cancer

被引：1269

作者：

Bartek, J ^{[1
]}

Lukas, J ^{[1
]}

机构：

[1] Danish Canc Soc, Inst Canc Biol, Dept Cell Cycle & Canc, DK-2100 Copenhagen, Denmark

来源：

CANCER CELL | 2003年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1535-6108(03)00110-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Accumulation of mutations and chromosomal aberrations is one of the hallmarks of cancer cells. This enhanced genetic instability is fueled by defects in the genome maintenance mechanisms including DNA repair and cell cycle checkpoint pathways. Here, we discuss the emerging roles of the mammalian Chk1 and Chk2 kinases as key signal transducers within the complex network of genome integrity checkpoints, as candidate tumor suppressors disrupted in sporadic as well as some hereditary malignancies and as potential targets of new anticancer therapies.

引用

页码：421 / 429

页数：9

共 88 条

[51] Checking in on Cds1 (Chk2): a checkpoint kinase and tumor suppressor [J].

McGowan, CH .

BIOESSAYS, 2002, 24 (06) :502-511

[52] Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations [J].

Meijers-Heijboer, H ;

van den Ouweland, A ;

Klijn, J ;

Wasielewski, M ;

de Snoo, A ;

Oldenburg, R ;

Hollestelle, A ;

Houben, M ;

Crepin, E ;

van Veghel-Plandsoen, M ;

Elstrodt, F ;

van Duijn, C ;

Bartels, C ;

Meijers, C ;

Schutte, M ;

McGuffog, L ;

Thompson, D ;

Easton, DF ;

Sodha, N ;

Seal, S ;

Barfoot, R ;

Mangion, J ;

Chang-Claude, J ;

Eccles, D ;

Eeles, R ;

Evans, DG ;

Houlston, R ;

Murday, V ;

Narod, S ;

Peretz, T ;

Peto, J ;

Phelan, C ;

Zhang, HX ;

Szabo, C ;

Devilee, P ;

Goldgar, D ;

Futreal, PA ;

Nathanson, KL ;

Weber, BL ;

Rahman, N ;

Stratton, MR .

NATURE GENETICS, 2002, 31 (01) :55-59

[53]

Menoyo A, 2001, CANCER RES, V61, P7727

[54] Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors [J].

Miller, CW ;

Ikezoe, T ;

Krug, U ;

Hofmann, WK ;

Tavor, S ;

Vegesna, V ;

Tsukasaki, K ;

Takeuchi, S ;

Koeffler, HP .

GENES CHROMOSOMES & CANCER, 2002, 33 (01) :17-21

[55] Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach [J].

O'Neill, T ;

Giarratani, L ;

Chen, P ;

Iyer, L ;

Lee, CH ;

Bobiak, M ;

Kanai, F ;

Zhou, BB ;

Chung, JH ;

Rathbun, GA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (18) :16102-16115

[56] Analysis of CHK2 in vulval neoplasia [J].

Reddy, A ;

Yuille, M ;

Sullivan, A ;

Repellin, C ;

Bell, A ;

Tidy, JA ;

Evans, DJ ;

Farrell, PJ ;

Gusterson, B ;

Gasco, M ;

Crook, T .

BRITISH JOURNAL OF CANCER, 2002, 86 (05) :756-760

[57] Molecular mechanism of the interaction between MDM2 and p53 [J].

Schon, O ;

Friedler, A ;

Bycroft, M ;

Freund, SMV ;

Fersht, AR .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 323 (03) :491-501

[58] Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility [J].

Schutte, M ;

Seal, S ;

Barfoot, R ;

Meijers-Heijboer, H ;

Wasielewski, M ;

Evans, DG ;

Eccles, D ;

Meijers, C ;

Lohman, F ;

Klijn, J ;

van den Ouweland, A ;

Futreal, PA ;

Nathanson, KL ;

Weber, BL ;

Easton, DF ;

Stratton, MR ;

Rahman, N .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (04) :1023-1028

[59] In search of the tumour-suppressor functions of BRCA1 and BRCA2 [J].

Scully, R ;

Livingston, DM .

NATURE, 2000, 408 (6811) :429-432

[60]

Shieh SY, 2000, GENE DEV, V14, P289

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