Postsynaptic calcium signaling microdomains in neurons

被引：28

作者：

Blackstone, C

Sheng, M

机构：

[1] NINCDS, Cellular Neurol Unit, NIH, Bethesda, MD 20892 USA

[2] MIT, RIKEN MIT Neurosci Res Ctr, Ctr Learning & Memory, Cambridge, MA 02139 USA

来源：

FRONTIERS IN BIOSCIENCE | 2002年 / 7卷

关键词：

postsynaptic density; PDZ domain; dendritic spine; review; calcium; neuron;

D O I：

10.2741/blacksto

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium ions are crucial messengers in the regulation of synaptic efficacy. In the postsynaptic neuron, this is exemplified by the tight temporal and spatial co-segregation of calcium ions with calcium-dependent signal transduction protein complexes in dendritic spines. Over the last several years optical imaging, physiological, structural, and biological studies have clarified the molecular mechanisms underlying differential calcium signaling within the spine. In this review, we discuss how calcium signaling "microdomains" are organized and regulated. We emphasize the structural and functional features of precisely regulated supramolecular complexes incorporating proteins involved in calcium influx, calcium efflux, and signal transduction. These complexes act in concert to orchestrate the sophisticated postsynaptic calcium signaling that underlies synaptic plasticity.

引用

页码：D872 / D885

页数：14

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[1] Interaction with the NMDA receptor locks CaMKII in an active conformation [J].