Mitotic Regulation The Fine Tuning of Separase Activity

被引：10

作者：

Agarwal, Ritu ^{[1
]}

Cohen-Fix, Orna ^{[1
]}

机构：

[1] NIDDK, Mol & Cellular Biol Lab, NIH, Bethesda, MD USA

来源：

CELL CYCLE | 2002年 / 1卷 / 04期

关键词：

Anaphase; Securin; Sister chromatid; separation;

D O I：

10.4161/cc.1.4.133

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitotic progression requires the dissolution of cohesion between sister chromatids. Cohesion is dissolved by an essential protease known as separase. Separase is highly conserved throughout evolution and is subjected to multiple levels of regulation. Here we discuss recent studies that unravel several key mechanisms for regulating separase activity.

引用

页码：253 / 255

页数：3

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