Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation

被引：147

作者：

Chu, Chen ^{[1
]}

Zhang, Haiya ^{[2
]}

Cui, Shijie ^{[3
]}

Han, Bin ^{[1
]}

Zhou, Lixiao ^{[1
]}

Zhang, Ning ^{[1
]}

Su, Xuan ^{[1
]}

Niu, Yujie ^{[2
,3
]}

Chen, Wen ^{[4
]}

Chen, Rui ^{[5
]}

Zhang, Rong ^{[1
,3
]}

Zheng, Yuxin ^{[6
]}

机构：

[1] Hebei Med Univ, Dept Toxicol, 361 Zhongshan East Rd, Shijiazhuang 050017, Hebei, Peoples R China

[2] Hebei Med Univ, Dept Occupat Hlth & Environm Hlth, Shijiazhuang 050017, Hebei, Peoples R China

[3] Hebei Prov Key Lab Environm & Human Hlth, Shijiazhuang 050017, Hebei, Peoples R China

[4] Sun Yat Sen Univ, Sch Publ Hlth, Dept Toxicol, Guangzhou 510080, Guangdong, Peoples R China

[5] Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med Engn, Dingjiaqiao 87, Nanjing 210009, Jiangsu, Peoples R China

[6] Qingdao Univ, Publ Hlth Coll, Dept Toxicol, Qingdao 266000, Shandong, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2019年 / 369卷

基金：

中国国家自然科学基金;

关键词：

PM2.5; Depression; Inflammation; NLRP3; Nrf2; EMERGENCY-DEPARTMENT VISITS; PARTICULATE MATTER PM2.5; AIR-POLLUTION; OXIDATIVE STRESS; NLRP3; INFLAMMASOME; GLOBAL BURDEN; RISK-FACTORS; ACTIVATION; BRAIN; DISEASE;

D O I：

10.1016/j.jhazmat.2019.02.026

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

PM2.5 pollution has been associated with numerous adverse effects including cardiovascular, respiratory and metabolic diseases as well as emotional disorders. However, the potential mechanism has not known clearly. Twenty-four rats were divided into 3 groups and exposed to various airs: filtered air (FA), unfiltered air (UA) and concentrated PM2.5 air (CA), respectively. Thirty wild type (WT) and 30 Nrf2 knockout (KO) mice were divided into 2 groups and exposed to FA and UA, respectively. The changes of neurobehavioral function, neurotransmitter secretion, toxic elements deposition, oxidative stress and the inflammation in prefrontal cortex were investigated during 9-12 weeks with/without PM2.5 exposure. Results showed that CA rats and KO-UA mice emerged obviously depressive-like responses. Li, Be, Al, Cr, Co, Ni, Se, Cd, Ba, Ti and Pb could deposit in the prefrontal cortex of rats after PM2.5 exposure. The neurotransmitters were significantly disorder in prefrontal cortex of CA rats. The NLRP3 signaling pathway was more activated in Nrf2(-/-) than WT mice after PM2.5 exposure for 9 weeks. Nrf2/NLRP3 signaling pathway modulating the inflammation might play an important role in the depression induced by ambient PM2.5.

引用

页码：180 / 190

页数：11

共 66 条

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