Compartmentalized and systemic control of tissue immunity by commensals

被引：283

作者：

Belkaid, Yasmine ^{[1
]}

Naik, Shruti ^{[1
]}

机构：

[1] NIAID, Mucosal Immunol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 07期

基金：

美国国家卫生研究院;

关键词：

DENDRITIC CELLS; INTESTINAL MICROBIOTA; GUT MICROBIOTA; GERM-FREE; SKIN; BACTERIA; DISEASE; DIVERSITY; DEFENSE; INFLAMMATION;

D O I：

10.1038/ni.2604

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The body is composed of various tissue microenvironments with finely tuned local immunosurveillance systems, many of which are in close apposition with distinct commensal niches. Mammals have formed an evolutionary partnership with the microbiota that is critical for metabolism, tissue development and host defense. Despite our growing understanding of the impact of this host-microbe alliance on immunity in the gastrointestinal tract, the extent to which individual microenvironments are controlled by resident microbiota remains unclear. In this Perspective, we discuss how resident commensals outside the gastrointestinal tract can control unique physiological niches and the potential implications of the dialog between these commensals and the host for the establishment of immune homeostasis, protective responses and tissue pathology.

引用

页码：646 / 653

页数：8

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