A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives

被引：19

作者：

Wang, Nengdong

Xiang, Jing

Ma, Zhibo

Quan, Junmin

Chen, Jiahua

Yang, Zhen ^{[1
]}

机构：

[1] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/cc800025n

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient and rapid solution-phase combinatorial synthesis of the SAG library was developed. The salient features for this library synthesis is the application of carbothioamide-derived palladacycle-catalyzed Suzuki coupling reactions for the parallel synthesis of a series of pyridine-based biaryl aldehydes under aerobic conditions and a direct N-alkylation of carbarnates using NaH as base in DMF in the presence of catalytic amount of water. The resultant library has been submitted to biological screening to evaluate their potential role in the regulation of Hedgehog pathway.

引用

收藏

页码：825 / 834

页数：10

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