Fighting arthritis with a senescence gene

被引:4
作者
Carson, DA [1 ]
Haneji, N [1 ]
机构
[1] Univ Calif San Diego, Sam & Rose Stein Inst Res Aging, La Jolla, CA 92093 USA
关键词
D O I
10.1038/10447
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The senescent phenotype is repressed in rheumatoid arthritis and can be restored by the p16INK4a tumor suppressor gene (pages 760–767).
引用
收藏
页码:731 / 732
页数:2
相关论文
共 7 条
[1]   Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer [J].
Cameron, EE ;
Bachman, KE ;
Myöhänen, S ;
Herman, JG ;
Baylin, SB .
NATURE GENETICS, 1999, 21 (01) :103-107
[2]   The INK4a/ARF tumor suppressor: one gene - two products - two pathways [J].
Chin, L ;
Pomerantz, J ;
DePinho, RA .
TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (08) :291-296
[3]   DELETIONS OF THE CYCLIN-DEPENDENT KINASE-4 INHIBITOR GENE IN MULTIPLE HUMAN CANCERS [J].
NOBORI, T ;
MIURA, K ;
WU, DJ ;
LOIS, A ;
TAKABAYASHI, K ;
CARSON, DA .
NATURE, 1994, 368 (6473) :753-756
[4]   A NEW REGULATORY MOTIF IN CELL-CYCLE CONTROL CAUSING SPECIFIC-INHIBITION OF CYCLIN-D/CDK4 [J].
SERRANO, M ;
HANNON, GJ ;
BEACH, D .
NATURE, 1993, 366 (6456) :704-707
[5]   Tumor surveillance via the ARF-p53 pathway [J].
Sherr, CJ .
GENES & DEVELOPMENT, 1998, 12 (19) :2984-2991
[6]  
Stein GH, 1999, MOL CELL BIOL, V19, P2109
[7]   Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis [J].
Taniguchi, K ;
Kohsaka, H ;
Inoue, N ;
Terada, Y ;
Ito, H ;
Hirokawa, K ;
Miyasaka, N .
NATURE MEDICINE, 1999, 5 (07) :760-767