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ARF-regulated phospholipase D: A potential role in membrane traffic

被引：49
作者：
Cockcroft, S
机构：
[1] Department of Physiology, Rockefeller Building, University College London, London WC1E 6JJ, University St.
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 1996年 / 80卷 / 1-2期
基金：
英国惠康基金;
关键词：
phospholipase D; ARF; small GTP binding proteins; Rho; PMA; protein kinase C; phosphatidylinositol bisphosphate; membrane traffic; phosphatidic acid;
D O I：
10.1016/0009-3084(96)02546-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phospholipase D activity is stimulated rapidly upon occupation of cell-surface receptors. One of the intracellular regulators of phospholipase D activity has been identified as ADP ribosylation factor (ARF). ARF is a small GTP binding protein whose function has been elucidated in vesicular traffic. This review puts into context the connection between the two fields of signal transduction and vesicular transport.
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页码：59 / 80
页数：22
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