Extracellular miRNAs as biomarkers in cancer

被引：30

作者：

Barger, Jennifer F. ^{[1
]}

Rahman, Mohammad A. ^{[1
]}

Jackson, Devine ^{[1
]}

Acunzo, Mario ^{[2
]}

Nana-Sinkam, S. Patrick ^{[1
,2
,3
]}

机构：

[1] Ohio State Univ, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[3] Ohio State Univ, James Comprehens Canc Ctr, Div Med Oncol, Columbus, OH 43210 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2016年 / 98卷

关键词：

MicroRNA; Extracellular vesicle; Cancer; Biomarker; Exosome; Clinical trial; SERUM EXOSOMAL MICRORNAS; BIOGENESIS; VESICLES; CELLS; IDENTIFICATION; SECRETION; MECHANISM; MICROVESICLES; LYMPHOCYTES; RECURRENCE;

D O I：

10.1016/j.fct.2016.06.010

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Cancer is the leading cause of death worldwide. Despite significant progress in the field leading to identification of molecular signatures of individual tumors and the development of targeted therapies, early cancer diagnosis remains a clinical challenge. The emerging era of personalized medicine has intensified research towards biomarkers that can be obtained via noninvasive means. The recent discovery of extracellular vesicles (EVs), nano-vesicles secreted by the cell, in circulation has stimulated interest in their clinical utility as cancer biomarkers. EVs are secreted from all types of cells and their contents reflect the physiological and pathological state of the cell. Multiple clinical trials are underway investigating the clinical potential of EV content to serve as biomarkers and therapeutics. However, much work remains to translate EV content into clinical application. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：66 / 72

页数：7

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