Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery

被引：13

作者：

Accardo, Antonella ^{[1
,2
]}

Mangiapia, Gaetano ^{[3
]}

Paduano, Luigi ^{[3
]}

Morelli, Giancarlo ^{[1
,2
]}

Tesauro, Diego ^{[1
,2
]}

机构：

[1] Univ Naples Federico II, Dept Biol Sci, CIRPeB, I-80134 Naples, Italy

[2] Univ Naples Federico II, IBB CNR, I-80134 Naples, Italy

[3] Univ Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy

来源：

JOURNAL OF PEPTIDE SCIENCE | 2013年 / 19卷 / 04期

关键词：

supramolecular aggregates; platinum complexes; drug delivery; octreotide; SANS; doxorubicin; ANGLE NEUTRON-SCATTERING; LIPOSOMAL-CISPLATIN; PHASE-I; GADOLINIUM COMPLEXES; CONTRAST AGENTS; SPI-077; NANOPARTICLES; NANOCAPSULES; CHEMISTRY; PEPTIDES;

D O I：

10.1002/psc.2481

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis, formulation and a complete physico-chemical characterization, by dynamic light scattering and small angle neutron scattering techniques, of new liposomal aggregates obtained by co-assembling an amphiphilic molecule containing a platinum complex, Peg1500-Lys(Pt-aminoEtGly)-Lys(C18)2, (abbreviated as (C18)2-PKAG-Pt), with a second amphiphilic monomer, (C18H37)2NCO(CH2)2CO(AdOO)5-Oct ((C18)2L5-Oct), containing the octreotide bioactive peptide, is reported. Liposomes of (C18)2-PKAG-Pt present a radius of 48nm, whereas the mixed aggregates (C18)2-PKAG-Pt/(C18)2L5-Oct at 90/10M ratio give larger liposomes with a radius of 84nm. In both cases, the bilayer thickness is similar to 5.3nm. Encapsulation of doxorubicin in mixed liposomes is also obtained by using the pH gradient method. The obtained liposomes could represent a new target selective cargo system for delivery of cisplatin based drugs and/or doxorubicin on cells overexpressing the sstr2 and sstr5 somatostatin receptors. Copyright (c) 2013 European Peptide Society and John Wiley & Sons, Ltd.

引用

页码：190 / 197

页数：8

共 48 条

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