Naposomes: a new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications

被引:8
作者
Accardo, Antonella
Morisco, Anna
Tesauro, Diego
Pedone, Carlo
Morelli, Giancarlo [1 ]
机构
[1] Univ Naples Federico II, Dept Biol Sci, Via Mezzocannone 16, I-80134 Naples, Italy
关键词
D O I
10.4155/TDE.10.86
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Modified supramolecular aggregates for selective delivery of contrast agents and/ or drugs are examined with a focus on a new class of peptide-derivatized nanoparticles: naposomes. These nanoparticles are based on the co-aggregation of two different amphiphilic monomers that give aggregates of different shapes and sizes (micelles, vesicles and liposomes) with diameters ranging between 10 and 300 nm. Structural properties and in vitro and in vivo behaviors are discussed. For the high relaxitivity values (12-19 mM(-1)s(-1)) and to detect for the presence of a surfaceexposed peptide, the new peptide-derived supramolecular aggregates are very promising candidates as targetselective MRI contrast agents. The efficiency of surface-exposed peptides in homing these nanovectors to a specific target introduces promising new opportunities for the development of diagnostic and therapeutic agents with high specificity toward the biological target and reduced toxic side effects on nontarget organs.
引用
收藏
页码:235 / 257
页数:23
相关论文
共 106 条
[1]   Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specific contrast agents in MRI [J].
Accardo, A ;
Tesauro, D ;
Roscigno, P ;
Gianolio, E ;
Paduano, L ;
D'Errico, G ;
Pedone, C ;
Morelli, G .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (10) :3097-3107
[2]  
ACCARDO A, 2010, J PEPT SCI, DOI DOI 10.1002/PSC.1308
[3]   Micelles by self-assembling peptide-conjugate amphiphile: synthesis and structural characterization [J].
Accardo, Antonella ;
Tesauro, Diego ;
Del Pozzo, Luigi ;
Mangiapia, Gaetano ;
Paduano, Luigi ;
Morelli, Giancarlo .
JOURNAL OF PEPTIDE SCIENCE, 2008, 14 (08) :903-910
[4]   Peptide-containing aggregates as selective nanocarriers for therapeutics [J].
Accardo, Antonella ;
Tesauro, Diego ;
Aloj, Luigi ;
Tarallo, Laura ;
Arra, Claudio ;
Mangiapia, Gaetano ;
Vaccaro, Mauro ;
Pedone, Carlo ;
Paduano, Luigi ;
Morelli, Giancarlo .
CHEMMEDCHEM, 2008, 3 (04) :594-602
[5]   Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers [J].
Accardo, Antonella ;
Tesauro, Diego ;
Mangiapia, Gaetano ;
Pedone, Carlo ;
Morelli, Giancarlo .
BIOPOLYMERS, 2007, 88 (02) :115-121
[6]   High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI [J].
Accardo, Antonella ;
Tesauro, Diego ;
Morelli, Giancarlo ;
Gianolio, Eliana ;
Aime, Silvio ;
Vaccaro, Mauro ;
Mangiapia, Gaetano ;
Paduano, Luigi ;
Schillen, Karin .
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2007, 12 (02) :267-276
[7]   Peptide modified nanocarriers for selective targeting of bombesin receptors [J].
Accardo, Antonella ;
Mansi, Rosalba ;
Morisco, Anna ;
Mangiapia, Gaetano ;
Paduano, Luigi ;
Tesauro, Diego ;
Radulescu, Aurel ;
Aurilio, Michela ;
Aloj, Luigi ;
Arra, Claudio ;
Morelli, Giancarlo .
MOLECULAR BIOSYSTEMS, 2010, 6 (05) :878-887
[8]   Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI [J].
Accardo, Antonella ;
Tesauro, Diego ;
Aloj, Luigi ;
Pedone, Carlo ;
Morelli, Giancarlo .
COORDINATION CHEMISTRY REVIEWS, 2009, 253 (17-18) :2193-2213
[9]   Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex [J].
Accardo, Antonella ;
Tesauro, Diego ;
Morisco, Anna ;
Mangiapia, Gaetano ;
Vaccaro, Mauro ;
Gianolio, Eliana ;
Heenan, Richard K. ;
Paduano, Luigi ;
Morelli, Giancarlo .
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2009, 14 (04) :587-599
[10]  
Aime S, 2000, CHEM-EUR J, V6, P2609, DOI 10.1002/1521-3765(20000717)6:14<2609::AID-CHEM2609>3.0.CO