Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers

被引：45

作者：

Accardo, Antonella

Tesauro, Diego

Mangiapia, Gaetano

Pedone, Carlo

Morelli, Giancarlo

机构：

[1] Univ Naples Federico II, Dept Biol Sci, CIRPeB, I-80134 Naples, Italy

[2] CNR, IBB, I-80134 Naples, Italy

[3] Univ Naples Federico II, Dept Chem, I-80126 Naples, Italy

来源：

BIOPOLYMERS | 2007年 / 88卷 / 02期

关键词：

peptide amphiphile; nanostructures; drug delivery; SANS; circular dichroism;

D O I：

10.1002/bip.20648

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The self-assembling behaviour, at physiological pH, of the amphiphile peptide (C18)(2)L5CCK8 in nanostructures is reported. Stable aggregates presenting a critical micellar concentration of 2 X 10(-6) mol kg(-1), and characterized by water exposed CCK8 peptide in P-sheet conformation, are obtained. Small angle neutron scattering experiments are indicative for a 3D structure with dimensions >= 100 nm. AFM images confirm the presence of nanostructures. Fluorescence experiments indicating the sequestration of pyrene, chosen as drug model, and the anticancer Doxorubicin within the nanostructures are reported. (c) 2006 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 115-121, 2007.

引用

页码：115 / 121

页数：7

共 26 条

[1] Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specific contrast agents in MRI [J].