A DECADE OF EXPERIENCE WITH DEEP BRAIN STIMULATION FOR PATIENTS WITH REFRACTORY MEDIAL TEMPORAL LOBE EPILEPSY

被引：96

作者：

Vonck, Kristl ^{[1
]}

Sprengers, Mathieu ^{[1
]}

Carrette, Evelien ^{[1
]}

Dauwe, Ine ^{[1
]}

Miatton, Marijke ^{[1
]}

Meurs, Alfred ^{[1
]}

Goossens, Lut ^{[1
]}

De Herdt, Veerle ^{[1
]}

Achten, Rik ^{[2
]}

Thiery, Evert ^{[1
]}

Raedt, Robrecht ^{[1
]}

Van Roost, Dirk ^{[3
]}

Boon, Paul ^{[1
]}

机构：

[1] Ghent Univ Hosp, Inst Neurosci, Dept Neurol, Reference Ctr Refractory Epilepsy, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Inst Neurosci, Dept Neuroradiol, B-9000 Ghent, Belgium

[3] Ghent Univ Hosp, Inst Neurosci, Dept Neurosurg, B-9000 Ghent, Belgium

来源：

INTERNATIONAL JOURNAL OF NEURAL SYSTEMS | 2013年 / 23卷 / 01期

关键词：

Neurostimulation; refractory epilepsy; deep brain stimulation; medial temporal lobe; INTRACTABLE PARTIAL EPILEPSY; HIPPOCAMPAL ELECTRICAL-STIMULATION; TERM-FOLLOW-UP; FUNCTIONAL CONNECTIONS; SEIZURE CONTROL; INTRACRANIAL ELECTRODES; CEREBELLAR STIMULATION; BILATERAL REDUCTIONS; ANTERIOR NUCLEUS; THALAMIC NUCLEI;

D O I：

10.1142/S0129065712500347

中图分类号：

TP18 [人工智能理论];

学科分类号：

140502 [人工智能];

摘要：

In this study, we present long-term results from patients with medial temporal lobe (MTL) epilepsy treated with deep brain stimulation (DBS). Since 2001, 11 patients (8M) with refractory MTL epilepsy underwent MTL DBS. When unilateral DBS failed to decrease seizures by > 90%, a switch to bilateral MTL DBS was proposed. After a mean follow-up of 8.5 years (range: 67-120 months), 6/11 patients had a >= 90% seizure frequency reduction with 3/6 seizure-free for > 3 years; three patients had a 40%-70% reduction and two had a < 30% reduction. In 3/5 patients switching to bilateral DBS further improved outcome. Uni-or bilateral MTL DBS did not affect neuropsychological functioning. This open study with an extended long-term follow-up demonstrates maintained efficacy of DBS for MTL epilepsy. In more than half of the patients, a seizure frequency reduction of at least 90% was reached. Bilateral MTL DBS may herald superior efficacy in unilateral MTL epilepsy.

引用

页数：13

共 85 条

[1]

How do the temporal lobes communicate in medial temporal lobe seizures? [J].