Type 1 interferons and the virus-host relationship:: A lesson in detente

被引：703

作者：

García-Sastre, A

Biron, CA ^{[1
]}

机构：

[1] Brown Univ, Dept Mol Microbiol & Immunol, Div Biol & Med, Providence, RI 02912 USA

[2] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

来源：

SCIENCE | 2006年 / 312卷 / 5775期

关键词：

D O I：

10.1126/science.1125676

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The interface between an infectious agent and its host represents the ultimate battleground for survival: The microbe must secure a niche for replication, whereas the host must limit the pathogen's advance. Among the host's arsenal of antimicrobial factors, the type 1 interferons (IFNs) induce potent defense mechanisms against viruses and are key in the host-virus standoff. Viruses have evolved multiple tricks to avoid the immediate antiviral effects of IFNs and, in turn, hosts have adapted use of this innate cytokine system to galvanize multiple additional layers of immune defense. The plasticity that exists in these interactions provides us with a lesson in detente.

引用

页码：879 / 882

页数：4

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