Enzyme inhibitory constituents from Duranta repens

被引：31

作者：

Anis, I ^{[1
]}

Ahmed, S ^{[1
]}

Malik, A ^{[1
]}

Yasin, A ^{[1
]}

Choudary, MI ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 04期

关键词：

Duranta repens; Verbenaceae; isoprenylated flavonoid and acetophenone; enzyme inhibitor;

D O I：

10.1248/cpb.50.515

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Isoprenylated flavonoids 5,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-3,6,4'-trimethoxyflavone (1), 3,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-5,6,4'-trimetboxyflavone (2) and an isoprenylated acetophenone derivative (3) have been isolated from Duranta repens along with known compounds, 5-hydroxy-3,6,7,4'-tetramethoxyflavone (4), rosenonolactone (5), 6,7-dimethoxycoumarin (6), 5alpha,8alpha-epidioxyergosta-6,2 2-dien-3beta-ol (7) and 5alpha,8alpha-epidioxyergosta-6,9(11),22-trien-3beta-ol (8), isolated for the first time from this species. Their structures and the relative configuration were determined by spectroscopic methods (H-1- and C-13-NMR, IR, UV and MS) and two-dimensional (2D)-NMR experiments. The compounds 1-5 showed inhibitory activity against prolyl endopeptidase while 4 and 5 were also active against thrombin.

引用

页码：515 / 518

页数：4

共 26 条

[1]

Anis I, 2001, HELV CHIM ACTA, V84, P649, DOI 10.1002/1522-2675(20010321)84:3&lt

[2]

649::AID-HLCA649&gt

[3]

3.0.CO

[4]

2-5

[5]

ACIDIC CONSTITUENTS OF DODONAEA LOBULATA [J].

DAWSON, RM ;

JARVIS, MW ;

JEFFERIES, PR ;

PAYNE, TG ;

ROSICH, RS .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1966, 19 (11) :2133-+

[6]

DELLAGRECA M, 1990, GAZZ CHIM ITAL, V120, P391

[7]

C-13 NMR-SPECTRA OF SOME ROSANE DITERPENOIDS [J].

DOCKERILL, B ;

HANSON, JR ;

SIVERNS, M .

PHYTOCHEMISTRY, 1978, 17 (03) :572-573

[8]

MINOR AND TRACE STEROLS IN MARINE-INVERTEBRATES .26. ISOLATION AND STRUCTURE ELUCIDATION OF 9 NEW 5-ALPHA,8-ALPHA-EPIDIOXY STEROLS FROM 4 MARINE ORGANISMS [J].

GUNATILAKA, AAL ;

GOPICHAND, Y ;

SCHMITZ, FJ ;

DJERASSI, C .

JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (19) :3860-3866

[9]

Lipohexin, a new inhibitor of prolyl endopeptidase from Moeszia lindtneri (HKI-0054) and Paecilomyces sp. (HKI-0055; HKI-0096) .1. Screening, isolation and structure Elucidation [J].

Heinze, S ;

Ritzau, M ;

Ihn, W ;

Hulsmann, H ;

Schlegel, B ;

Dornberger, K ;

Fleck, WF ;

Zerlin, M ;

Christner, C ;

Grafe, U ;

Kullertz, G ;

Fischer, G .

JOURNAL OF ANTIBIOTICS, 1997, 50 (05) :379-383

[10]

NEW ESTERS, 2-(4-HYDROXY-3-METHOXYPHENYL)ETHYL HEXACOSANOATES AND OCTACOSANOATES FROM THE LEAVES OF CINNAMOMUM-RETICULATUM HAY [J].

KUO, YH ;

SHUE, MJ .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1991, 38 (01) :65-69

← 1 2 3 →