Lipohexin, a new inhibitor of prolyl endopeptidase from Moeszia lindtneri (HKI-0054) and Paecilomyces sp. (HKI-0055; HKI-0096) .1. Screening, isolation and structure Elucidation

被引：21

作者：

Heinze, S

Ritzau, M

Ihn, W

Hulsmann, H

Schlegel, B

Dornberger, K

Fleck, WF

Zerlin, M

Christner, C

Grafe, U

Kullertz, G

Fischer, G

机构：

[1] HANS KNOLL INST NAT PROD RES,D-07745 JENA,GERMANY

[2] MAX PLANCK ARBEITSGRP ENZYMOL PEPTIDBINDUNG,D-06120 HALLE,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 05期

关键词：

D O I：

10.7164/antibiotics.50.379

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lipohexin was isolated as a novel lipohexapeptide (I) (C39H68N6O9) from three fungal strains, Moeszia lindtneri HKI-0054, Paecilomyces sp. HKI-0055 and Paecilomyces sp. HKI-0096. The structure was elucidated by detailed mass spectrometric and NMR experiments. The proline-containing peptide displays moderate antibacterial activity against Bacillus subtilis ATCC 6633 and inhibits competitively the prolyl endopeptidase from human placenta.

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页码：379 / 383

页数：5

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