Chiasma formation: chromatin/axis interplay and the role(s) of the synaptonemal complex

被引:238
作者
Kleckner, N [1 ]
机构
[1] Harvard Univ, Herchel Smith Prof Mol Biol, Cambridge, MA 02138 USA
关键词
D O I
10.1007/s00412-006-0055-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Meiotic recombination proceeds in biochemical complexes that are physically associated with underlying chromosome structural axes. In this study, we discuss the organizational basis for these axes, the timing and nature of recombinosome/axis organization with respect to the prophase program of DNA and to structural changes, and the possible significance of axis organization. Furthermore, we discuss implications and extensions of our recently proposed mechanical model for chiasma formation. Finally, we give a broader consideration to past and present models for the role of the synaptonemal complex.
引用
收藏
页码:175 / 194
页数:20
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