Mutations in the gyrA and parC genes associated with fluoroquinolone resistance in clinical isolates of Citrobacter freundii

被引：12

作者：

Nishino, Y ^{[1
]}

Deguchi, T ^{[1
]}

Yasuda, M ^{[1
]}

Kawamura, T ^{[1
]}

Nakano, M ^{[1
]}

Kanematsu, E ^{[1
]}

Ozeki, S ^{[1
]}

Kawada, Y ^{[1
]}

机构：

[1] GIFU UNIV,SCH MED,DEPT UROL,GIFU 500,JAPAN

来源：

FEMS MICROBIOLOGY LETTERS | 1997年 / 154卷 / 02期

关键词：

Citrobacter freundii; DNA gyrase; Topoisomerase IV;

D O I：

10.1016/S0378-1097(97)00361-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We determined partial sequences of the gyrA and parC genes of Citrobacter freundii type strain, and then examined 38 C. freundii clinical strains isolated from patients with urinary tract infections for the association of alterations in GyrA and ParC with susceptibility to fluoroquinolones. Our results suggest that in C. freundii DNA gyrase may be a primary target of quinolones, that an amino acid change at Thr-83 or Asp-87 in GyrA is sufficient to decrease susceptibility to fluoroquinolones, and that accumulation of changes in GyrA with the simultaneous presence of an alteration at Ser-80 or Glu-84 in ParC may be associated with the development of high-level fluoroquinolone resistance in C. freundii clinical isolates.

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收藏

页码：409 / 414

页数：6

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