Brain tumor epidemiology: Consensus from the Brain Tumor Epidemiology Consortium

被引:617
作者
Bondy, Melissa L. [1 ]
Scheurer, Michael E. [2 ]
Malmer, Beatrice [3 ]
Barnholtz-Sloan, Jill S. [4 ]
Davis, Faith G. [5 ]
Il'Yasova, Dora [6 ]
Kruchko, Carol [7 ]
McCarthy, Bridget J. [5 ,7 ]
Rajaraman, Preetha [8 ]
Schwartzbaum, Judith A. [9 ]
Sadetzki, Siegal [10 ]
Schlehofer, Brigitte [11 ]
Tihan, Tarik [12 ]
Wiemels, Joseph L. [13 ]
Wrensch, Margaret [14 ]
Buffler, Patricia A. [15 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Pediat, Dan L Duncan Canc Ctr, Houston, TX 77030 USA
[3] Umea Univ, Dept Radiat Sci & Oncol, Umea, Sweden
[4] Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA
[5] Univ Illinois, Sch Publ Hlth, Div Epidemiol Biostat, Chicago, IL USA
[6] Duke Univ, Med Ctr, Duke Comprehens Canc Ctr, Dept Community & Family Med, Durham, NC 27710 USA
[7] Cent Brain Tumor Registry US, Hinsdale, IL USA
[8] NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
[9] Ohio State Univ, Sch Publ Hlth, Div Epidemiol, Columbus, OH 43210 USA
[10] Chaim Sheba Med Ctr, Gertner Inst, Canc & Radiat Epidemiol Unit, IL-52621 Tel Hashomer, Israel
[11] German Canc Res Ctr, Environm Epidemiol Unit, D-6900 Heidelberg, Germany
[12] Univ Calif San Francisco, Dept Pathol, San Francisco, CA USA
[13] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[14] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA
[15] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA 94720 USA
关键词
glioma; meningioma; epidemiology; genetics;
D O I
10.1002/cncr.23741
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Epidemiologists in the Brain Tumor Epidemiology Consortium (BTEC) have prioritized areas for further research. Although many risk factors have been examined over the past several decades, there are few consistent findings, possibly because of small sample sizes in individual studies and differences between studies in patients, tumor types, and methods of classification. Individual studies generally have lacked samples of sufficient size to examine interactions. A major priority based on available evidence and technologies includes expanding research in genetics and molecular epidemiology of brain tumors. BTEC has taken an active role in Promoting understudied groups, such as pediatric brain tumors; the etiology of rare glioma subtypes, such as oligodendroglioma; and meningioma, which, although it is not uncommon, has only recently, been registered systematically in the United States. There also is a pressing need for more researchers, especially junior investigators, to study brain tumor epidemiology. However, relatively poor funding for brain tumor research has made it difficult to encourage careers in this area. In this report, BTEC epidemiologists reviewed the groups Consensus oil the Current state of scientific findings, and they present a consensus oil research priorities to identify which important areas the science should move to address.
引用
收藏
页码:1953 / 1968
页数:16
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