A candidate gene approach to searching for low-penetrance breast and prostate cancer genes

被引：143

作者：

Hunter, DJ ^{[1
]}

Riboli, E ^{[1
]}

Haiman, CA ^{[1
]}

Albanes, D ^{[1
]}

Altshuler, D ^{[1
]}

Chanock, SJ ^{[1
]}

Hayes, RB ^{[1
]}

Henderson, BE ^{[1
]}

Kaaks, R ^{[1
]}

Stram, DO ^{[1
]}

Thomas, G ^{[1
]}

Thun, MJ ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 12期

关键词：

D O I：

10.1038/nrc1754

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium - a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer - was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers - the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway - and to associate these variations with cancer risk.

引用

页码：977 / 985

页数：9

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