A candidate gene approach to searching for low-penetrance breast and prostate cancer genes

被引：143

作者：

Hunter, DJ ^{[1
]}

Riboli, E ^{[1
]}

Haiman, CA ^{[1
]}

Albanes, D ^{[1
]}

Altshuler, D ^{[1
]}

Chanock, SJ ^{[1
]}

Hayes, RB ^{[1
]}

Henderson, BE ^{[1
]}

Kaaks, R ^{[1
]}

Stram, DO ^{[1
]}

Thomas, G ^{[1
]}

Thun, MJ ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 12期

关键词：

D O I：

10.1038/nrc1754

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium - a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer - was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers - the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway - and to associate these variations with cancer risk.

引用

页码：977 / 985

页数：9

共 97 条

[51]

LI WH, 1991, GENETICS, V129, P513

[52] Environmental and heritable factors in the causation of cancer - Analyses of cohorts of twins from Sweden, Denmark, and Finland. [J].

Lichtenstein, P ;

Holm, NV ;

Verkasalo, PK ;

Iliadou, A ;

Kaprio, J ;

Koskenvuo, M ;

Pukkala, E ;

Skytthe, A ;

Hemminki, K .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (02) :78-85

[53] DIRECT STIMULATORY EFFECTS OF INSULIN-LIKE GROWTH FACTOR-I ON LEYDIG-CELL STEROIDOGENESIS IN PRIMARY CULTURE [J].

LIN, T ;

HASKELL, J ;

VINSON, N ;

TERRACIO, L .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 137 (03) :950-956

[54] CLINICAL AND BIOCHEMICAL PARAMETERS OF ANDROGEN ACTION IN NORMAL HEALTHY CAUCASIAN VERSUS CHINESE SUBJECTS [J].

LOOKINGBILL, DP ;

DEMERS, LM ;

WANG, C ;

LEUNG, A ;

RITTMASTER, RS ;

SANTEN, RJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (06) :1242-1248

[55] Genetic defects of the growth hormone-insulin-like growth factor axis [J].

López-Bermejo, A ;

Buckway, CK ;

Rosenfeld, RG .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2000, 11 (02) :39-49

[56] Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia [J].

Mantzoros, CS ;

Tzonou, A ;

Signorello, LB ;

Stampfer, M ;

Trichopoulos, D ;

Adaml, HO .

BRITISH JOURNAL OF CANCER, 1997, 76 (09) :1115-1118

[57] Single-nucleotide polymorphisms in the public domain: how useful are they? [J].

Marth, G ;

Yeh, R ;

Minton, M ;

Donaldson, R ;

Li, Q ;

Duan, SG ;

Davenport, R ;

Miller, RD ;

Kwok, PY .

NATURE GENETICS, 2001, 27 (04) :371-372

[58] P450 ENZYMES OF ESTROGEN METABOLISM [J].

MARTUCCI, CP ;

FISHMAN, J .

PHARMACOLOGY & THERAPEUTICS, 1993, 57 (2-3) :237-257

[59]

McKean-Cowdin R, 2001, CANCER RES, V61, P848

[60]

Michnovicz J J, 1988, Steroids, V52, P69, DOI 10.1016/0039-128X(88)90218-8

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