Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: Systematic review

被引:75
作者
Bloch, Michael H. [1 ,2 ]
Landeros-Weisenberger, Angeli [1 ]
Sen, Srijan [2 ]
Dombrowski, Philip [1 ]
Kelmendi, Ben [2 ]
Coric, Vladimir [2 ]
Pittenger, Christopher [2 ]
Leckman, James F. [1 ]
机构
[1] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
基金
美国国家卫生研究院;
关键词
obsessive-compulsive disorder; serotonin transporter polymorphism; meta-analysis;
D O I
10.1002/ajmg.b.30699
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We investigated the association between the long (1) and short (s) alleles of the serotonin transporter polymorphism (5-HTTLPR) in the promoter region of the SLC6A4 gene and obsessive-compulsive disorder (OCD) using meta-analysis to combine all published data from case-control and family based association studies (2,283 cases). In stratified meta-analysis we investigated whether age of sample (child and adult), ethnicity (Caucasian and Asian) and study design (case-control and family-based association studies) moderated any association. In the overall meta-analysis we found no evidence of association between genetic variation at the 5-HTTLPR locus and OCD. We did find significant heterogeneity between studies. In the stratified meta-analyses, we demonstrated a significant association between the I-allele and OCD in family-based association studies and in studies involving children and Caucasians. Our meta-analysis suggests the possibility that the I-allele may be associated with OCD in specific OCD subgroups such as childhood-onset OCD and in Caucasians. Further meta-analyses based on individual patient data would be helpful in determining whether age of OCD onset, gender and the presence of comorbid illness (e.g., ties) moderates the relationship between 5-HTTLPR and OCD. (c) 2008 Wiley-Liss, Inc.
引用
收藏
页码:850 / 858
页数:9
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