Two new compounds from Atractylodes macrocephala with neuroprotective activity

被引：65

作者：

Zhang, Na ^{[1
]}

Liu, Chao ^{[1
]}

Sun, Tie-Min ^{[2
]}

Ran, Xiao-Ku ^{[1
]}

Kang, Ting-Guo ^{[1
]}

Dou, De-Qiang ^{[1
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Peoples R China

[2] Shenyang Pharmaceut Univ, Coll Pharmaceut Engn, Shenyang 110016, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 01期

关键词：

Atractylodes macrocephala; atractylenolide; neuroprotective effect; RHIZOMES; LACTONES; KOIDZ;

D O I：

10.1080/10286020.2016.1247351

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

In the present study, two new compounds, together with six known compounds, were isolated from rhizome of Atractylodes macrocephala Koidz by a series of silica gel, ODS column chromatography, and preparative HPLC. Their structures were characterized as atractylenolide II (1), atractylenolide I (2), biepiasterolid (3), isoatractylenolide I (4), atractylenolide III (5), 3-acetoxyl atractylenolide I (6), (4E,6E,12E)-tetradeca-4,6,12-triene-8,10-diyne-13,14-triol (7), (3S,4E,6E,12E)-1-acetoxy-tetradeca-4,6,12-triene-8,10-diyne-3,14-diol (8) on the basis of 1D, 2D NMR, and circular dichroism analyses. Among them, compounds 6 and 8 were novel compounds. In addition, their neuroprotective activity against MPP+-induced SH-SY5Y cells was evaluated by MTT colorimetry. The results showed that all these compounds have definite protective effect on MPP+-induced SH-SY5Y cells.

引用

页码：35 / 41

页数：7

共 9 条

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