Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid

被引：31

作者：

Takahashi, K

Sone, M

Satoh, F

Murakami, O

Totsune, K

Tanji, H

Sato, N

Ito, H

Mouri, T

机构：

[1] NATL IWATE HOSP, DEPT INTERNAL MED, ICHINOSEKI, IWATE 021, JAPAN

[2] TOHOKU UNIV, SCH MED, DEPT INTERNAL MED 2, SENDAI, MIYAGI 98077, JAPAN

[3] MOURI CLIN, DIV NEUROENDOCRINOL, NATORI, MIYAGI 98112, JAPAN

来源：

PEPTIDES | 1997年 / 18卷 / 03期

关键词：

adrenomedullin; cerebrospinal fluid; radioimmunoassay; chromatography; choroid plexus;

D O I：

10.1016/S0196-9781(96)00328-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 +/- 3.1 pmol/l (mean +/- SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin(1-52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid. (C) 1997 Elsevier Science Inc.

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收藏

页码：459 / 461

页数：3

相关论文

共 19 条

[1] DISTRIBUTION AND CHARACTERIZATION OF IMMUNOREACTIVE ADRENOMEDULLIN IN HUMAN TISSUE AND PLASMA [J].

ICHIKI, Y ;

KITAMURA, K ;

KANGAWA, K ;

KAWAMOTO, M ;

MATSUO, H ;

ETO, T .

FEBS LETTERS, 1994, 338 (01) :6-10

[2] ADRENOMEDULLIN - A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA [J].

KITAMURA, K ;

KANGAWA, K ;

KAWAMOTO, M ;

ICHIKI, Y ;

NAKAMURA, S ;

MATSUO, H ;

ETO, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (02) :553-560

[3] CLONING AND CHARACTERIZATION OF CDNA-ENCODING A PRECURSOR FOR HUMAN ADRENOMEDULLIN [J].

KITAMURA, K ;

SAKATA, J ;

KANGAWA, K ;

KOJIMA, M ;

MATSUO, H ;

ETO, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 194 (02) :720-725

[4] IMMUNOREACTIVE ADRENOMEDULLIN IN HUMAN PLASMA [J].

KITAMURA, K ;

ICHIKI, Y ;

TANAKA, M ;

KAWAMOTO, M ;

EMURA, J ;

SAKAKIBARA, S ;

KANGAWA, K ;

MATSUO, H ;

ETO, T .

FEBS LETTERS, 1994, 341 (2-3) :288-290

[5] EXPRESSION OF ADRENOMEDULLIN IN NORMAL HUMAN LUNG AND IN PULMONARY TUMORS [J].

MARTINEZ, A ;

MILLER, MJ ;

UNSWORTH, EJ ;

SIEGFRIED, JM ;

CUTTITTA, F .

ENDOCRINOLOGY, 1995, 136 (09) :4099-4105

[6] THE NOVEL VASOACTIVE HORMONE, ADRENOMEDULLIN, INHIBITS WATER DRINKING IN THE RAT [J].

MURPHY, TC ;

SAMSON, WK .

ENDOCRINOLOGY, 1995, 136 (06) :2459-2463

[7] AN ABUNDANT AND SPECIFIC BINDING-SITE FOR THE NOVEL VASODILATOR ADRENOMEDULLIN IN THE RAT [J].

OWJI, AA ;

SMITH, DM ;

COPPOCK, HA ;

MORGAN, DGA ;

BHOGAL, R ;

GHATEI, MA ;

BLOOM, SR .

ENDOCRINOLOGY, 1995, 136 (05) :2127-2134

[8] A NOVEL VASOACTIVE PEPTIDE, ADRENOMEDULLIN, INHIBITS PITUITARY ADRENOCORTICOTROPIN RELEASE [J].

SAMSON, WK ;

MURPHY, T ;

SCHELL, DA .

ENDOCRINOLOGY, 1995, 136 (05) :2349-2352

[9] CHARACTERIZATION OF IMMUNOREACTIVE ADRENOMEDULLIN IN HUMAN PLASMA AND URINE [J].

SATO, K ;

HIRATA, Y ;

IMAI, T ;

IWASHINA, M ;

MARUMO, F .

LIFE SCIENCES, 1995, 57 (02) :189-194

[10] ADRENOMEDULLIN IN HUMAN BRAIN, ADRENAL-GLANDS AND TUMOR-TISSUES OF PHEOCHROMOCYTOMA, GANGLIONEUROBLASTOMA AND NEUROBLASTOMA [J].

SATOH, F ;

TAKAHASHI, K ;

MURAKAMI, O ;

TOTSUNE, K ;

SONE, M ;

OHNEDA, M ;

ABE, K ;

MIURA, Y ;

HAYASHI, Y ;

SASANO, H ;

MOURI, T .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (05) :1750-1752