Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid

被引：31

作者：

Takahashi, K

Sone, M

Satoh, F

Murakami, O

Totsune, K

Tanji, H

Sato, N

Ito, H

Mouri, T

机构：

[1] NATL IWATE HOSP, DEPT INTERNAL MED, ICHINOSEKI, IWATE 021, JAPAN

[2] TOHOKU UNIV, SCH MED, DEPT INTERNAL MED 2, SENDAI, MIYAGI 98077, JAPAN

[3] MOURI CLIN, DIV NEUROENDOCRINOL, NATORI, MIYAGI 98112, JAPAN

来源：

PEPTIDES | 1997年 / 18卷 / 03期

关键词：

adrenomedullin; cerebrospinal fluid; radioimmunoassay; chromatography; choroid plexus;

D O I：

10.1016/S0196-9781(96)00328-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 +/- 3.1 pmol/l (mean +/- SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin(1-52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid. (C) 1997 Elsevier Science Inc.

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收藏

页码：459 / 461

页数：3

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