Post-transcriptional regulons coordinate the initiation and resolution of inflammation

被引:220
作者
Anderson, Paul [1 ]
机构
[1] Brigham & Womens Hosp, Dept Med, Div Rheumatol, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
TUMOR-NECROSIS-FACTOR; MESSENGER-RNA STABILITY; AU-RICH-ELEMENT; T-CELL-ACTIVATION; CD40 LIGAND EXPRESSION; 60S RIBOSOMAL-SUBUNIT; IL-2; GENE-EXPRESSION; BINDING PROTEIN HUR; FACTOR-ALPHA; TNF-ALPHA;
D O I
10.1038/nri2685
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Transcriptional control mechanisms chart the course of the inflammatory response by synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these mRNAs can be long-lived, turning off their synthesis does not rapidly stop or change the direction of inflammation. Post-transcriptional mechanisms that modify mRNA stability and/or translation provide more rapid and flexible control of this process and are particularly important in coordinating the initiation and resolution of inflammation. Here, I review the surprising variety of post-transcriptional control mechanisms that regulate the initiation and resolution of inflammation and discuss how these mechanisms are integrated to coordinate this essential process.
引用
收藏
页码:24 / 35
页数:12
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