Mercury(II) Recognition and Fluorescence Imaging in Vitro through a 3D-Complexation Structure

被引：39

作者：

Ho, Mei-Lin ^{[1
]}

Chen, Kew-Yu ^{[2
]}

Lee, Gene-Hsiang ^{[2
]}

Chen, Yu-Chun ^{[2
]}

Wang, Chih-Chieh ^{[1
]}

Lee, Jyh-Fu ^{[3
]}

Chung, Wen-Chun ^{[1
]}

Chou, Pi-Tai ^{[2
]}

机构：

[1] Soochow Univ, Dept Chem, Taipei, Taiwan

[2] Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan

[3] Natl Synchrotron Radiat Res Ctr, Hsinchu 300, Taiwan

来源：

INORGANIC CHEMISTRY | 2009年 / 48卷 / 21期

关键词：

SELECTIVE DETECTION; AQUEOUS-SOLUTION; HG2+; SENSOR; WATER; CHEMOSENSOR; 7-HYDROXYQUINOLINES; PROBE;

D O I：

10.1021/ic901613s

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

8,8'-(1,4,10,13-Tetrathia-7,16-diazacyclooctadecane-7,16-diyl)-bis(methylene)diquinolin-7-ol (TTBQ) was synthesized and proved to selectively recognize Hg2+, forming a Hg2+/TTBQ complex with an association constant (K-a) as large as similar to 1.3 x 10(4) +/- 520 M-1 in aqueous solution. Single crystals of TTBQ and a TTBQ-Hg2+ complex have also been successfully grown, in which the latter unambiguously revealed a cagelike configuration consisting of thiol-crown and dual 7-hydroxyquinoline moieties to firmly trap Hg2+. This 3D-complexation structure accounts for similar to 25-fold luminescence enhancement and a detection limit of sub-mu M in water for sensing Hg2+. Great selectivity toward Hg2+ has been exhibited over alkali- and alkaline-earth metal ions, first-row transition-metal ions, and other cations studied. This chemosensor is particularly suited for the detection of Hg2+ in a pH range of 5.5 to 7.5. This, in combination with its fine biocompatibility, leads to the success toward in vitro mercury recognition based on fluorescence imaging.

引用

页码：10304 / 10311

页数：8

共 33 条

[1] Probing the behavior of confined water by proton-transfer reactions [J].