PTSD is Associated With an Excess of Inflammatory Immune Activities

被引：192

作者：

Gill, Jessica M. ^{[1
]}

Saligan, Leo

Woods, Stephanie ^{[2
]}

Page, Gayle ^{[3
]}

机构：

[1] NINR, NIH, Bethesda, MD 20892 USA

[2] Univ Akron, Sch Nursing, Akron, OH 44325 USA

[3] Johns Hopkins Univ, Sch Nursing, Bethesda, MD USA

来源：

PERSPECTIVES IN PSYCHIATRIC CARE | 2009年 / 45卷 / 04期

关键词：

Cortisol; immune; inflammatory; PTSD; trauma; POSTTRAUMATIC-STRESS-DISORDER; C-REACTIVE PROTEIN; COMBAT VETERANS; CYTOKINE PRODUCTION; PARTNER VIOLENCE; RECEPTOR; CORTISOL; INTERLEUKIN-6; WOMEN; PHYSIOLOGY;

D O I：

10.1111/j.1744-6163.2009.00229.x

中图分类号：

R47 [护理学];

学科分类号：

1011 ;

摘要：

PURPOSE. Post-traumatic stress disorder (PTSD) is associated with inflammatory-related medical conditions. This review examines studies of immune function in individuals with PTSD to determine if excessive inflammation is associated with PTSD. CONCLUSIONS. Current studies suggest an excess of inflammatory actions of the immune system in individuals with chronic PTSD. High levels of inflammatory cytokines have also been linked to PTSD vulnerability in traumatized individuals. There is also evidence that excessive inflammation is in part due to insufficient regulation by cortisol. PRACTICE IMPLICATIONS. An excess of inflammatory immune activity may contribute to health declines in individuals with PTSD, and treating PTSD symptoms may reduce these risks.

引用

收藏

页码：262 / 277

页数：16

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