Enhanced cellular immune response in women with PTSD related to childhood abuse

被引：83

作者：

Altemus, M

Cloitre, M

Dhabhar, FS

机构：

[1] Weill Med Coll, Dept Psychiat, New York, NY 10021 USA

[2] NYU, Ctr Child Study, New York, NY USA

[3] Ohio State Univ, Coll Med, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[4] Ohio State Univ, Coll Dent, Dept Oral Biol, Columbus, OH 43210 USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2003年 / 160卷 / 09期

关键词：

D O I：

10.1176/appi.ajp.160.9.1705

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Disturbed regulation of both the hypothalamic-pituitary-adrenal (HPA) axis and the sympathoadrenomedullary system in posttraurnatic stress disorder (PTSD) suggests that immune function, which is modulated by these systems, also may be dysregulated in individuals with PTSD. Method: Delayed-type hypersensitivity skin test responses were measured in 16 women with PTSD due to childhood sexual or physical abuse and 15 women who did not have a history of abuse, other trauma, or psychiatric disorders. HPA axis activity was assessed by examination of circadian salivary cortisol levels and a single time point measurement of plasma cortisol. Results: Delayed-type hypersensitivity was enhanced in women with PTSD. Cortisol measures did not differ between PTSD and healthy comparison subjects. Conclusions: These results suggest that cell-mediated inflammatory reactions are greater in individuals with PTSD.

引用

收藏

页码：1705 / 1707

页数：3

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