A blood-borne antigen induces rapid T-B cell contact:: a potential mechanism for tolerance induction

被引:10
作者
Gütgemann, I
Darling, JM
Greenberg, HB
Davis, MM
Chien, YH
机构
[1] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Med, Stanford, CA 94305 USA
[3] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA
关键词
D O I
10.1046/j.1365-2567.2002.01527.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Understanding the difference between the development of a productive T-cell response and tolerance is central to discerning how the immune system functions. Intravenous injection of soluble protein is thought to mimic the presentation of self-serum and orally introduced antigens. It is generally toleragenic. The current view is that this outcome reflects the failure of 'immunogenic' dendritic cells to relocate to the T-cell zone of the secondary lymphoid tissues. Here, using a peptide/I-E-k tetramer and antibodies to stain splenic sections, we showed that antigen-specific T cells were activated in the spleen within hours of injection or feeding of protein. The activated T cells were found to be located at the T-B junction, the bridging zone and the B-cell area, interacting directly with B cells. In addition, B cells gain the ability to present antigen. Our results suggest a way for T cells to be stimulated by blood-borne antigen presented by naive B cells, a potential mechanism of tolerance induction.
引用
收藏
页码:420 / 425
页数:6
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