Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives

被引：56

作者：

Allin, SM ^{[1
]}

Northfield, CJ

Page, MI

Slawin, AMZ

机构：

[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] Univ Huddersfield, Dept Chem & Biol Sci, Huddersfield HD1 3DH, W Yorkshire, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 11期

关键词：

D O I：

10.1039/b001569p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New methodology for the synthesis of non-racemic isoindolinone targets has been developed through application of tricyclic gamma-lactam substrates as N-acyliminium ion precursors in reactions with carbon and hydride nucleophiles. Removal of the phenylglycinol derived chiral auxiliary can be achieved without loss of stereochemical integrity at the newly created asymmetric centre, and we report a novel method for this key step using conc. sulfuric acid.

引用

页码：1715 / 1721

页数：7

共 29 条

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