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A novel therapeutic approach to depression via supplement with tyrosine hydroxylase

被引：43
作者：
Ai Ling Fu [1 ]
Shao Ping Wu
Zhao Hui Dong
Man Ji Sun
机构：
[1] Fudan Univ, Inst Neurobiol, Shanghai 200433, Peoples R China
[2] Inst Pharmacol & Toxicol, Dept Biochem & Pharmacol, Beijing 100850, Peoples R China
[3] Beijing Ctr Dis Prevent, Beijing 100013, Peoples R China
[4] Beijing Ctr Control, Beijing 100013, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 351卷 / 01期
关键词：
tyrosine hydroxylase; depression; anti-depressant; protein transduction domain; protein therapy;
D O I：
10.1016/j.bbrc.2006.10.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要：
Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons. The regulated activity of TH is thought to play a critical role in modulating the functional activity of catecholaminergic neuronal systems in the brain. It is well known that the catecholaminergic neuronal systems are associated with depression. Here we showed that TH, delivered by protein transduction domain (PTD), passed through the blood-brain barrier and entered the neurons. Systemic TH treatment improved the behavioral despair in the forced swim test (FST) and the tail suspension test (TST), the two models widely used to screen the potential anti-depressant efficacy. The results indicated a novel and potential therapeutic use of TH in the depression disorder. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：140 / 145
页数：6
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