Sodium-iodide symporter (NIS)-mediated accumulation of [211AT]astatide in NIS-transfected human cancer cells

被引：41

作者：

Carlin, S ^{[1
]}

Mairs, RJ

Welsh, P

Zalutsky, MR

机构：

[1] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA

[2] Univ Glasgow, Dept Radiat Oncol, Canc Res UK Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2002年 / 29卷 / 07期

关键词：

astatine-211; iodine-13; 1; sodium-iodide symporter; NIS; radiotherapy; alpha-particles;

D O I：

10.1016/S0969-8051(02)00332-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [At-211]astatide in the UVW human glioma cell line transfected to express NIS. [At-211]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [I-131]iodide uptake. These studies suggest [At-211]astatide as a possible alternative radionuclide to [I-131]iodide for NIS-based endoradiotherapy, and provide a model for the study of [At-211]astatide behavior at a cellular level. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：729 / 739

页数：11

共 27 条

[21] Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa [J].