Indomethacin protects against neurodegeneration caused by MPTP intoxication in mice

被引：70

作者：

Kurkowska-Jastrzebska, I

Babiuch, M

Joniec, I

Przybylkowski, A

Czlonkowski, A

Czlonkowska, A

机构：

[1] Inst Psychiat & Neurol, Dept Neurol 2, Warsaw, Poland

[2] Med Acad Warsaw, Dept Pharmacol, Warsaw, Poland

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2002年 / 2卷 / 08期

关键词：

non-steroid anti-inflammatory agents; microglia; inflammation; neurodegeneration;

D O I：

10.1016/S1567-5769(02)00078-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anti-inflammatory agents are postulated to be effective in treating neurodegenerative disorders. in this study, we showed that indomethacin (IND) in the dose of 1 mg/kg protected neurons against toxic damage caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice model of Parkinson's disease. IND also diminished microglial activation and lymphocytic infiltration in the injured areas. These observations suggest that anti-inflammatory properties of IND may play a role in the neuron's protection in this model. However, diminished inflammatory reaction may be secondary to less neuronal damage.

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收藏

页码：1213 / 1218

页数：6

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