DNA repair: RAD alert

被引:24
作者
Ivanov, EL
Haber, JE
机构
[1] BRANDEIS UNIV,ROSENSTIEL BASIC MED SCI RES CTR,WALTHAM,MA 02254
[2] BRANDEIS UNIV,DEPT BIOL,WALTHAM,MA 02254
关键词
D O I
10.1016/S0960-9822(06)00246-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mammalian homologues of two important yeast genes involved in DNA double-strand break repair and recombination, RAD51 and RAD54, have been isolated, Knock-out mutations of the genes in mice reveal both reassuring similarities to, and surprising differences from, the analogous mutant phenotypes in yeast.
引用
收藏
页码:R492 / R495
页数:4
相关论文
共 21 条
  • [1] NUCLEOTIDE-SEQUENCE AND TRANSCRIPTIONAL REGULATION OF THE YEAST RECOMBINATIONAL REPAIR GENE RAD51
    BASILE, G
    AKER, M
    MORTIMER, RK
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (07) : 3235 - 3246
  • [2] BAUMANN P, 1996, CELL, V87, P57
  • [3] Reduced X-ray resistance and homologous recombination frequencies in a RAD54(-/-) mutant of the chicken DT40 cell line
    Bezzubova, O
    Silbergleit, A
    YamaguchiIwai, Y
    Takeda, S
    Buerstedde, JM
    [J]. CELL, 1997, 89 (02) : 185 - 193
  • [4] Disruption of mouse RAD54 reduces ionizing radiation resistance
    Essers, J
    Hendriks, RW
    Swagemakers, SMA
    Troelstra, C
    deWit, J
    Bootsma, D
    Hoeijmakers, JHJ
    Kanaar, R
    [J]. CELL, 1997, 89 (02) : 195 - 204
  • [5] IN-VIVO BIOCHEMISTRY - PHYSICAL MONITORING OF RECOMBINATION INDUCED BY SITE-SPECIFIC ENDONUCLEASES
    HABER, JE
    [J]. BIOESSAYS, 1995, 17 (07) : 609 - 620
  • [6] Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: Evidence for functional conservation
    Kanaar, R
    Troelstra, C
    Swagemakers, SMA
    Essers, J
    Smit, B
    Franssen, JH
    Pastink, A
    Bezzubova, OY
    Buerstedde, JM
    Clever, B
    Heyer, WD
    Hoeijmakers, JHJ
    [J]. CURRENT BIOLOGY, 1996, 6 (07) : 828 - 838
  • [7] Chromosomal double-strand break repair in Ku80-deficient cells
    Liang, F
    Romanienko, PJ
    Weaver, DT
    Jeggo, PA
    Jasin, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (17) : 8929 - 8933
  • [8] Lim DS, 1996, MOL CELL BIOL, V16, P7133
  • [9] A human RNA polymerase II complex associated with SRB and DNA-repair proteins
    Maldonado, E
    Shiekhattar, R
    Sheldon, M
    Cho, H
    Drapkin, R
    Rickert, P
    Lees, E
    Anderson, CW
    Linn, S
    Reinberg, D
    [J]. NATURE, 1996, 381 (6577) : 86 - 89
  • [10] MALKOVA A, 1996, P NATL ACAD SCI USA, V93, P131