Palladium(II)-Catalyzed ortho Alkylation of Benzoic Acids with Alkyl Halides

被引：229

作者：

Zhang, Yang-Hui ^{[1
]}

Shi, Bing-Feng ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 33期

基金：

美国国家卫生研究院;

关键词：

alkylation; benzoic acid; benzolactones; C-H activation; C-H ACTIVATION; PALLADIUM-CATALYZED ARYLATION; ARYL HALIDES; DIRECT FUNCTIONALIZATION; COUPLING REACTIONS; BOND ACTIVATION; DERIVATIVES; CLEAVAGE; HETEROCYCLES; TOSYLATES;

D O I：

10.1002/anie.200902262

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Outsmarting the competition: In the PdII-catalyzed reaction of benzoates with alkyl halides, an aryl C-H bond is activated before the competitive alkylation of the carboxylate anion can takes place. The alkylation reaction was followed by an intramolecular lactonization to give broadly useful γ- and δ-benzolactones (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6097 / 6100

页数：4

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