Maturation of function in dendritic cells for tolerance and immunity

被引：75

作者：

Quah, BJC ^{[1
]}

O'Neill, HC ^{[1
]}

机构：

[1] Australian Natl Univ, Sch Biochem & Mol Sci, Canberra, ACT 0200, Australia

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2005年 / 9卷 / 03期

关键词：

dendritic cells; immunity; tolerance; exosomes;

D O I：

10.1111/j.1582-4934.2005.tb00494.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The capacity of antigen presenting dendritic cells (DC) to function in both tolerance and immunity is now well documented. The function and characteristics of different DC subsets are reviewed here and their capacity to activate T cells under different conditions of maturation and activation is discussed. The immunogenic potential of exosomes produced by DC is also considered in light of evidence that the capacity of exosomes to activate T cells for tolerance or immunity appears to mirror that of the parent DC. A model is proposed whereby exosomes produced by immature DC can function to maintain peripheral tolerance, while exosomes produced by more mature DC can stimulate effector T cells.

引用

页码：643 / 654

页数：12

共 105 条

[1] A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells [J].

Adema, GJ ;

Hartgers, F ;

Verstraten, R ;

deVries, E ;

Marland, G ;

Menon, S ;

Foster, J ;

Xu, YM ;

Nooyen, P ;

McClanahan, T ;

Bacon, KB ;

Figdor, CG .

NATURE, 1997, 387 (6634) :713-717

[2]

AGGER R, 1990, International Reviews of Immunology, V6, P89, DOI 10.3109/08830189009056621

[3] Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen [J].

Akbari, O ;

DeKruyff, RH ;

Umetsu, DT .

NATURE IMMUNOLOGY, 2001, 2 (08) :725-731

[4] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[5] Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells [J].

Albert, ML ;

Jegathesan, M ;

Darnell, RB .

NATURE IMMUNOLOGY, 2001, 2 (11) :1010-1017

[6] Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].

Albert, ML ;

Sauter, B ;

Bhardwaj, N .

NATURE, 1998, 392 (6671) :86-89

[7] Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes [J].

Albert, ML ;

Pearce, SFA ;

Francisco, LM ;

Sauter, B ;

Roy, P ;

Silverstein, RL ;

Bhardwaj, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (07) :1359-1368

[8] Exosomes as potent cell-free peptide-based vaccine.: I.: Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells [J].

André, F ;

Chaput, N ;

Schartz, NEC ;

Flament, C ;

Aubert, N ;

Bernard, J ;

Lemonnier, F ;

Raposo, G ;

Escudier, B ;

Hsu, DH ;

Tursz, T ;

Amigorena, S ;

Angevin, E ;

Zitvogel, L .

JOURNAL OF IMMUNOLOGY, 2004, 172 (04) :2126-2136

[9] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[10] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

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