Antibacterial activity of aminals and hemiaminals of pyrazole and imidazole

被引：24

作者：

Lupsor, Simona ^{[2
]}

Aonofriesei, Florin ^{[1
]}

Iovu, Mircea ^{[3
]}

机构：

[1] Ovidius Univ Constanta, Fac Nat Sci & Agr Sci, Dept Biol Ecol, Constanta 900347, Romania

[2] Ovidius Univ Constanta, Dept Chem, Fac Phys Chem Elect & Petr Chem, Constanta 900527, Romania

[3] Carol Davila Univ Bucharest, Fac Pharm, Dept Chem, Bucharest 020956, Romania

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期

关键词：

Antibacterial activity; Aminals; Hemiaminals; Pyrazole; Imidazole; BIOLOGICAL EVALUATION; MYCOBACTERIUM-TUBERCULOSIS; FORMALDEHYDE; CATALYSIS; CONSTANTS; ACID;

D O I：

10.1007/s00044-011-9839-2

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Antibacterial activity of 1,1'-methylenedipyrazole (AM1), 1-hydroxymethylpyrazole (SAM1), 1,1'-methylenediimidazole (AM2), and 1-hydroxymethylimidazole (SAM2) has been tested against reference and clinical strains by both difusimetric and broth dilution methods. Overall, the minimal inhibitory concentrations of tested compounds ranged from 180 to 270 mu g/ml, while the minimal bactericidal concentrations were between 360 and 720 mu g/ml. Comparative assessment with phenol and formaldehyde shows that AM1, AM2, SAM1, and SAM2 have moderate to good antibacterial activity.

引用

页码：3035 / 3042

页数：8

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