Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism

被引：208

作者：

Buescher, Joerg Martin ^{[2
]}

Liebermeister, Wolfram ^{[3
]}

Jules, Matthieu ^{[4
]}

Uhr, Markus ^{[1
]}

Muntel, Jan ^{[5
]}

Botella, Eric

Hessling, Bernd ^{[5
]}

Kleijn, Roelco Jacobus ^{[2
]}

Le Chat, Ludovic ^{[4
]}

Lecointe, Francois ^{[4
]}

Maeder, Ulrike ^{[5
]}

Nicolas, Pierre ^{[6
]}

Piersma, Sjouke ^{[8
]}

Ruegheimer, Frank ^{[16
,17
]}

Becher, Doerte ^{[5
]}

Bessieres, Philippe ^{[6
]}

Bidnenko, Elena

Denham, Emma L. ^{[8
,9
]}

Dervyn, Etienne

Devine, Kevin M. ^{[7
]}

Doherty, Geoff ^{[10
]}

Drulhe, Samuel ^{[16
,17
]}

Felicori, Liza ^{[11
]}

Fogg, Mark J. ^{[12
]}

Goelzer, Anne ^{[6
]}

Hansen, Annette ^{[7
]}

Harwood, Colin R. ^{[13
]}

Hecker, Michael

Hubner, Sebastian ^{[7
]}

Hultschig, Claus ^{[14
]}

Jarmer, Hanne ^{[15
]}

Klipp, Edda ^{[3
]}

Leduc, Aurelie ^{[6
]}

Lewis, Peter ^{[10
]}

Molina, Frank

Noirot, Philippe ^{[4
]}

Peres, Sabine

Pigeonneau, Nathalie ^{[4
]}

Pohl, Susanne ^{[13
]}

Rasmussen, Simon ^{[15
]}

Rinn, Bernd ^{[14
]}

Schaffer, Marc

Schnidder, Julian ^{[2
]}

Schwikowski, Benno ^{[16
,17
]}

Van Dijl, Jan Maarten ^{[8
,9
]}

Veiga, Patrick

Walsh, Sean ^{[14
]}

Wilkinson, Anthony J. ^{[12
]}

Stelling, Joerg ^{[1
]}

Aymerich, Stephane ^{[4
]}

机构：

[1] ETH, Dept Biosyst Sci & Engn, CH-4058 Basel, Switzerland

[2] ETH, Inst Mol Syst Biol, CH-8093 Basel, Switzerland

[3] Humboldt Univ, D-10115 Berlin, Germany

[4] INRA, UMR1319 Micalis, F-78350 Jouy En Josas, France

[5] Ernst Moritz Arndt Univ Greifswald, Inst Microbiol, D-17487 Greifswald, Germany

[6] INRA, UR1077, F-78350 Jouy En Josas, France

[7] Trinity Coll Dublin, Smurfit Inst Genet, Dublin 2, Ireland

[8] Univ Groningen, Dept Med Microbiol, NL-9700 RB Groningen, Netherlands

[9] Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

[10] Univ Newcastle, Sch Environm & Life Sci, Callaghan, NSW 2308, Australia

[11] Sysdiag CNRS Bio Rad, UMR 3145, F-34184 Montpellier 4, France

[12] Univ York, York Struct Biol Lab, Dept Chem, York YO10 5YW, N Yorkshire, England

[13] Univ Newcastle Tyne, Ctr Bacterial Cell Biol, Newcastle Upon Tyne NE2 4AX, Tyne & Wear, England

[14] ETH, Ctr Informat Sci & Databases, Dept Biosyst Sci & Engn, CH-4058 Basel, Switzerland

[15] Tech Univ Denmark, Ctr Biol Sequence Anal, Dept Syst Biol, DK-2800 Lyngby, Denmark

[16] Inst Pasteur, Syst Biol Lab, Dept Genomes & Genet, F-75015 Paris, France

[17] CNRS, URA 2171, F-75015 Paris, France

来源：

SCIENCE | 2012年 / 335卷 / 6072期

基金：

英国医学研究理事会;

关键词：

TRANSCRIPTIONAL REGULATION; ESCHERICHIA-COLI; YEAST; RECONSTRUCTION; STARVATION; COMPLEXITY; SYSTEMS;

D O I：

10.1126/science.1206871

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.

引用

页码：1099 / 1103

页数：5

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