Anticancer activities of novel chalcone and bis-chalcone derivatives

被引：366

作者：

Modzelewska, A

Pettit, C

Achanta, G

Davidson, NE

Huang, P

Khan, SR ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Div Chem Therapeut, Baltimore, MD 21231 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 10期

关键词：

anticancer; chalcone; bis-chalcone; Claisen-Schmidt reaction;

D O I：

10.1016/j.bmc.2006.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel chalcones and bis-chalcones containing boronic acid moieties has been synthesized and evaluated for antitumor activity against the human breast cancer MDA-MB-231 (estrogen receptor-negative) and MCF7 (estrogen receptor-positive) cell lines and against two normal breast epithelial cell lines, MCF-10A and MCF-12A. These molecules inhibited the growth of the human breast cancer cell lines at low micromolar to nanomolar concentrations, with five of them (1-4, 9) showing preferential inhibition of the human breast cancer cell lines. Furthermore, bis-chalcone 8 exhibited a more potent inhibition of colon cancer cells expressing wild-type p53 than of an isogenic cell line that was p53-null. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：3491 / 3495

页数：5

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