Sintokamides A to E, Chlorinated Peptides from the Sponge Dysidea sp that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells

被引：125

作者：

Sadar, Marianne D. ^{[1
]}

Williams, David E. ^{[2
,3
]}

Mawji, Nasrin R. ^{[1
]}

Patrick, Brian O. ^{[2
]}

Wikanta, Thamrin ^{[4
]}

Chasanah, Ekowati ^{[4
]}

Irianto, Hari Eko ^{[4
]}

Van Soest, Rob ^{[5
]}

Andersen, Raymond J. ^{[2
,3
]}

机构：

[1] British Columbia Canc Agcy, Genome Sci Ctr, Vancouver, BC V5Z 4E6, Canada

[2] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[3] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1, Canada

[4] Res Ctr Marine & Fisheries Prod Proc & Biotechnol, Jakarta 10260, Indonesia

[5] Univ Amsterdam, Inst Systemat & Ecol, NL-1090 GT Amsterdam, Netherlands

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 21期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/ol802021w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new chlorinated peptides sintokamides A to E (1-5) have been isolated from specimens of the marine sponge Dysidea sp. collected in Indonesia. Their structures were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Sintokamide A (1) is an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells.

引用

页码：4947 / 4950

页数：4

共 23 条

[1]

CHARLES C, 1978, TETRAHEDRON LETT, V19, P1519

[2] NOVEL SPONGE DERIVED AMINO-ACIDS .17. A NOVEL CHLORINATED KETIDE AMINO-ACID, HERBAMIDE-A, FROM THE MARINE SPONGE DYSIDEA-HERBACEA [J].

CLARK, WD ;

CREWS, P .

TETRAHEDRON LETTERS, 1995, 36 (08) :1185-1188

[3] New chlorinated metabolites from the tropical marine sponge Dysidea herbacea [J].

Dumdei, EJ ;

Simpson, JS ;

Garson, MJ ;

Byriel, KA ;

Kennard, CHL .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1997, 50 (02) :139-144

[4] NEW POLYCHLORINATED METABOLITES FROM A BARRIER-REEF COLLECTION OF THE SPONGE DYSIDEA-HERBACEA [J].

ERICKSON, KL ;

WELLS, RJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1982, 35 (01) :31-38

[5] Geographic variation of natural products of tropical nudibranch Asteronotus cespitosus [J].

Fahey, SJ ;

Garson, MJ .

JOURNAL OF CHEMICAL ECOLOGY, 2002, 28 (09) :1773-1785

[6] ON ENANTIOMORPH-POLARITY ESTIMATION [J].

FLACK, HD .

ACTA CRYSTALLOGRAPHICA SECTION A, 1983, 39 (NOV) :876-881

[7] Characterization of the initial enzymatic steps of barbamide biosynthesis [J].

Flatt, Patricia M. ;

O'Connell, Susan J. ;

McPhail, Kerry L. ;

Zeller, Gloria ;

Willis, Christine L. ;

Sherman, David H. ;

Gerwick, William H. .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (06) :938-944

[8] Dysideaprolines A-F and barbaleucamides A-B, novel polychlorinated compounds from a Dysidea species [J].

Harrigan, GG ;

Goetz, GH ;

Luesch, H ;

Yang, ST ;

Likos, J .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (09) :1133-1138

[9] DYSIDIN, A NOVEL CHLORINE CONTAINING NATURAL PRODUCT FROM SPONGE DYSIDEA-HERBACEA [J].

HOFHEINZ, W ;

OBERHANSLI, WE .

HELVETICA CHIMICA ACTA, 1977, 60 (02) :660-669

[10]

KAZLAUSKAS R, 1977, TETRAHEDRON LETT, V18, P3183

← 1 2 3 →