Resveratrol inhibits EMMPRIN expression via p38 and ERK1/2 pathways in PMA-induced THP-1 cells

被引：96

作者：

Huang, Zhouqing ^{[1
]}

Wang, Changqian ^{[1
]}

Wei, Li ^{[2
]}

Wang, Jun ^{[2
]}

Fan, Yuqi ^{[3
]}

Wang, Liansheng ^{[1
]}

Wang, Yue ^{[1
]}

Chen, Ting ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, XinHua Hosp, Dept Cardiol, Shanghai 200092, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Traumatol & Orthopaed, Shanghai 200025, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Cardiol, Shanghai 200001, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 374卷 / 03期

关键词：

resveratrol; extracellular matrix metalloproteinase inducer (EMMPRIN); Mitogen-activated protein kinase (MAPK); phorbol 12-myristate 13-acetate (PMA); THP-1; cell;

D O I：

10.1016/j.bbrc.2008.07.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The extracellular matrix metalloproteinase inducer (EMMPRIN) is significant in the regulation of matrix metalloproteinase (MMP) synthesis in atherosclerosis-related cells, and is possibly involved in the progression of atherosclerotic plaque. EMMPRIN expression is also up-regulated in PMA-induced THP-1 cells and is inhibited by resveratrol. However, it remains unclear how resveratrol inhibits EMMPRIN expression. We thus investigated the role of the MAPK signaling pathway in resveratrol inhibiting the up-regulation of EMMPRIN in PMA-induced THP-1 cells. We found that the ERK1/2 and p38 pathways, but not the JNK, are activated during the up-regulation of EMMPRIN expression. We also observed that while resveratrol Suppresses the up-regulation of EMMPRIN, it also suppresses both the ERK1/2 and p38 pathways in a dose-dependent manner. Taken together, we established that it is through both the ERK1/2 and p38 MAPK pathways that resveratrol inhibits the expression of EMMPRIN in PMA-induced THP-1 cells. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：517 / 521

页数：5

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