Endothelial Cells Form a Phalanx to Block Tumor Metastasis

被引：20

作者：

Bautch, Victoria L. ^{[1
,2
,3
]}

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Carolina Cardiovasc Biol Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

CELL | 2009年 / 136卷 / 05期

关键词：

THERAPY; HYPOXIA; DOMAIN;

D O I：

10.1016/j.cell.2009.02.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor blood vessels deliver oxygen poorly, thereby contributing to tumor hypoxia and upregulation of proangiogenic cytokines in an escalating feedback loop. Mazzone et al. (2009) now show that reducing the amount of a protein involved in endothelial oxygen sensing leads to changes in endothelial cell shape that interrupt this feedback loop and reduce tumor metastasis.

引用

收藏

页码：810 / 812

页数：3

相关论文

共 9 条

[1] Modes of resistance to anti-angiogenic therapy [J].

Bergers, Gabriele ;

Hanahan, Douglas .

NATURE REVIEWS CANCER, 2008, 8 (08) :592-603

[2] Activation of the VEGFR1 chromatin domain -: An angiogenic signal-ETS1/HIF-2α regulatory axis [J].

Dutta, Debasree ;

Ray, Soma ;

Vivian, Jay L. ;

Paul, Soumen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (37) :25404-25413

[3] Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis [J].

Hanahan, D ;

Folkman, J .

CELL, 1996, 86 (03) :353-364

[4] Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy [J].

Jain, RK .

SCIENCE, 2005, 307 (5706) :58-62

[5] INHIBITION OF VASCULAR ENDOTHELIAL-CELL GROWTH-FACTOR ACTIVITY BY AN ENDOGENOUSLY ENCODED SOLUBLE RECEPTOR [J].

KENDALL, RL ;

THOMAS, KA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (22) :10705-10709

[6] HIF-2α specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites [J].

Le Bras, A. ;

Lionneton, F. ;

Mattot, V. ;

Lelievre, E. ;

Caetano, B. ;

Spruyt, N. ;

Soncin, F. .

ONCOGENE, 2007, 26 (53) :7480-7489

[7] Targeting HIF-1 for cancer therapy [J].

Semenza, GL .

NATURE REVIEWS CANCER, 2003, 3 (10) :721-732

[8] Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5 [J].

Taddei, Andrea ;

Giampietro, Costanza ;

Conti, Annarita ;

Orsenigo, Fabrizio ;

Breviario, Ferruccio ;

Pirazzoli, Valentina ;

Potente, Michael ;

Daly, Christopher ;

Dimmeler, Stefanie ;

Dejana, Elisabetta .

NATURE CELL BIOLOGY, 2008, 10 (08) :923-934

[9] Placental but not heart defects are associated with elevated hypoxia-inducible factor α levels in mice lacking prolyl hydroxylase domain protein 2 [J].

Takeda, Kotaro ;

Ho, Vivienne C. ;

Takeda, Hiromi ;

Duan, Li-Juan ;

Nagy, Andras ;

Fong, Guo-Hua .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (22) :8336-8346